Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymalfibrotic characteristics 英文参考文献.docVIP

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Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymalfibrotic characteristics 英文参考文献.doc

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Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymalfibrotic characteristics 英文参考文献

Available online /content/8/6/R165 Research article Open Access Vol 8 No 6 Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics Marjan MC Steenvoorden1,2, Tanja CA Tolboom1, Gabri van der Pluijm3, Clemens L?wik3, Cornelis PJ Visser4, Jeroen DeGroot2, Adriana C Gittenberger-DeGroot5, Marco C DeRuiter5, Bert J Wisse5, Tom WJ Huizinga1 and René EM Toes1 1Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands 2TNO Quality of Life, Business Unit Biomedical Research, Zernikedreef 9, 2333 CK Leiden, The Netherlands 3Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands 4Department of Orthopaedics, Rijnland Hospital, Simon Smitweg 1, 2353 GA Leiderdorp, The Netherlands 5Department of Anatomy and Embryology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands Corresponding author: René EM Toes, R.E.M.Toes@lumc.nl Received: 4 Jul 2006 Revisions requested: 9 Aug 2006 Revisions received: 28 Sep 2006 Accepted: 31 Oct 2006 Published: 31 Oct 2006 Arthritis Research Therapy 2006, 8:R165 (doi:10.1186/ar2073) This article is online at: /content/8/6/R165 ? 2006 Steenvoorden et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The healthy synovial lining layer consists of a single cell layer that regulates the transport between the joint cavity and the surrounding tissue. It has been suggested that abnormalities such as somatic mutations in the p53 tumor-suppressor gene contribute to synovial hyperplasia and invasion in rheumatoid arthritis (RA). In this study, expression of epithelial marke