Transcriptional slippage in bacteria distribution in sequenced genomes and utilization in IS element gene expression 英文参考文献.docVIP

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Transcriptional slippage in bacteria distribution in sequenced genomes and utilization in IS element gene expression 英文参考文献.doc

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Transcriptional slippage in bacteria distribution in sequenced genomes and utilization in IS element gene expression 英文参考文献

Open Access Re rch 2005BaranovetVoal.lumesea6, Issue 3, Article R25 Transcriptional slippage in bacteria: distribution in sequenced genomes and utilization in IS element gene expression Pavel V Baranov*?, Andrew W Hammer*, Jiadong Zhou*?, Raymond F Gesteland* and John F Atkins*? Addresses: *Department of Human Genetics, University of Utah, Salt Lake City, UT 84112-5330, USA. ?Bioscience Institute, University College Cork, Cork, Ireland. ?Current address: Gene Technology Division, Nitto Denko Technical Corporation, 401 Jones Road, Oceanside, CA 92054, USA. Correspondence: John F Atkins. E-mail: atkins@ Published: 15 February 2005 Received: 27 August 2004 Revised: 16 December 2004 Accepted: 25 January 2005 Genome Biology 2005, 6:R25 The electronic version of this article is the complete one and can be found online at /2005/6/3/R25 ? 2005 Baranov et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. HomopolymerictpiavpgeerTufoonrfsirnoedfgAualalaentnidogrunsntThooofffingdseilfnbacterialifpeepreeaxngpter-leepsnrgenomessonegiothns.sequencesin/p108 bacatterwhichial genselectionomes wasagainstanalyzetranscriptionald. IS eleme t gslippageenes wereisfevident,ound to ethexpltranscriptionoit transcriptiofnrepeti-al slip- Abstract Background: Transcription slippage occurs on certain patterns of repeat mononucleotides, resulting in synthesis of a heterogeneous population of mRNAs. Individual mRNA molecules within this population differ in the number of nucleotides they contain that are not specified by the template. When transcriptional slippage occurs in a coding sequence, translation of the resulting mRNAs yields more than one protein product. Except where the products of the resulting mRNAs have distinct