Transcriptional responses to biologically relevant doses of UV-B radiation in the model archaeon, Halobacterium sp. NRC-1 英文参考文献.docVIP

Saline Systems BioMedCentral Research Open Access Transcriptional responses to biologically relevant doses of UV-B radiation in the model archaeon, Halobacterium sp. NRC-1 Ivan Boubriak?1,6, Wooi Loon Ng?2, Priya DasSarma?3, Shiladitya DasSarma*3,4, David J Crowley5 and Shirley J McCready*2 Address: 1Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK, 2School of Life Sciences, Oxford Brookes University, Gipsy Lane, Oxford OX3 0BP, UK, 3Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 E. Pratt St., Suite 236, Baltimore, MD 21202, USA, 4Molecular and Structural Biology Program, Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA, 5Natural Sciences Department, Assumption College, 500 Salisbury Street, Worcester, Massachusetts 01609, USA and 6Institute of Cell Biology and Genetic Engineering, UAS, 148 Zabolotnogo Street, Kiev, 03143, Ukraine Email: Ivan Boubriak - ivan.boubriak@bichem.ox.ac.uk; Wooi Loon Ng - wooiloon.ng@brookes.ac.uk; Priya DasSarma - dassarmp@; Shiladitya DasSarma* - dassarma@; David J Crowley - dacrowle@; Shirley J McCready* - sjmccready@brookes.ac.uk * Corresponding authors ?Equal contributors Published: 29 August 2008 Received: 2 April 2008 Accepted: 29 August 2008 Saline Systems 2008, 4:13 doi:10.1186/1746-1448-4-13 This article is available from: /content/4/1/13 ? 2008 Boubriak et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Most studies of the transcriptional response to UV radiation in living cells have used UV doses that are much higher than those encountered in the natural environment, and most focus on short-wave UV (UV-C) at 254 nm, a wavelength that never reaches the Earths