Translating genome sequences into biological understanding 英文参考文献.docVIP

Meeting report Translating genome sequences into biological understanding Vishwanath R Iyer Address: Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA. E-mail: vishy@ Published: 23 May 2003 Genome Biology 2003, 4:324 The electronic version of this article is the complete one and can be found online at /2003/4/6/324 ? 2003 BioMed Central Ltd Cell-type- or tissue-specific expression at specific develop- A report on the Genomics, Proteomics and Bioinformatics Thematic Meeting during the 2003 American Society for mental stages, which provides clues about gene function, can therefore be analyzed. Second, the ES cell lines can be used to generate mice with null alleles of the targeted genes. More than 150 knockout mice have been generated by the consor- tium and these too will be available for distribution. Biochemistry and Molecular Biology (ASBMB) Annual Meeting, San Diego, USA, 11-15 April 2003. April 2003 marked the fiftieth anniversary of the discovery of the double-helical structure of DNA and also the announcement of the finished human genome sequence. The period between the first outline of the DNA double-helix and the grand revelation of the human genome has yielded the complete genome sequences of many other organisms. It was apt that the theme of the 2003 ASBMB Annual Meeting was ‘Translating the Genome’, referring to the challenge of converting sequence information into biological insights; talks at the meeting highlighted various approaches being developed to meet this challenge. Brian Seed (Harvard Medical School, Boston, USA) described an automated approach for identifying mam- malian cDNAs that can activate specific signaling pathways or transcription factors. A reporter system was constructed, consisting of green fluorescent protein (GFP) controlled by a signaling-responsive promoter in