Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb the role of estrogen receptors 英文参考文献.docVIP

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Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb the role of estrogen receptors 英文参考文献.doc

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Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb the role of estrogen receptors 英文参考文献

Vollmeretal.ChineseMedicine2010,5:7 /content/5/1/7 REVIEW OpenAccess Treatmentofmenopausalsymptomsbyan extractfromtherootsofrhaponticrhubarb:the roleofestrogenreceptors GünterVollmer*,AnjaPapke,OliverZierau Abstract Adryextractfromtherootsofrhaponticrhubarb(extractRheumrhaponticum(L.);ERr)hasbeencommercially availableinGermanyforovertwodecadestotreatmenopausalsymptoms.However,themolecularbasisofits clinicaleffectivenessremainsobscure.Thisarticlereviewstheinvitroandinvivodataofitsestrogenicactions,par- ticularlythosemediatedbyestrogenreceptor-b(ERb). Background years) prior to the last menstruation. About 80% of A dry extract from the roots of rhapontic rhubarb menopausal women suffer from hot flushes, sweating, (extract Rheum rhaponticum (L.); ERr; Dahuang) con- heartcomplaints,sleepdisturbances,depression,anxiety, sistsmainlyofrhaponticin(90%)andaglycones(5%)of physical/mental exhaustion, sexual problems, urinary rhaponticinanddesoxyrhaponticin(Figure1).Inplants, tractcomplaintsandvaginaldryness. thesenaturalhydroxystilbene compoundsshareacom- While hormone therapy (HT) effectively relieves monbiosyntheticpathwaywithresveratrolwhichisthe menopausal symptoms, many women seek alternative first stilbene compound produced from p-coumaroyl- treatments due to increased risks for breast [7] and CoAcatalysedbyaselectivestilbenesynthesis.Allother endometrial cancer [8] associated with HT, as well as hydroxystilbenes inRheumrhaponticumarederivatives venous thromboembolism. The effectiveness of ERr to ofresveratrol[1]. treatmenopausalsymptomswasvalidatedbya3-month Noadverseeventshavebeenobservedinhumanappli- prospectiverandomizedcontrolledtrialon54perimeno- cationsofERralthoughthesyntheticestrogendiethylstil- pausal women with climacteric complaints receiving a bestrol with astructural similarity ofhydroxystilbenes dailydoseof4mgofERr.ThetreatmentwithERrafter exertsdeleterioustransplacentaleffectsinhumans[2,3]. 12 weeks significa