Trojan Microparticles for Drug Delivery 英文参考文献.docVIP

Pharmaceutics 2012, 4, 1-25; doi:10.3390/pharmaceutics4010001 OPEN ACCESS pharmaceutics ISSN 1999-4923 /journal/pharmaceutics Review Trojan Microparticles for Drug Delivery Nicolas Anton, Anshuman Jakhmola and Thierry F. Vandamme * Laboratoire de Conception et d’Applications de Molécules Bioactives, Faculty of Pharmacy, University of Strasbourg, CNRS 7199, 74 route du Rhin, 67400 Illkirch, France * Author to whom correspondence should be addressed; E-Mail: vandamme@unistra.fr; Tel.: +33-3-688-541-06; Fax: +33-3-688-543-06. Received: 9 December 2011; in revised form: 20 December 2011 / Accepted: 4 January 2012 / Published: 6 January 2012 Abstract: During the last decade, the US Food and Drug Administration (FDA) have regulated a wide range of products, (foods, cosmetics, drugs, devices, veterinary, and tobacco) which may utilize micro and nanotechnology or contain nanomaterials. Nanotechnology allows scientists to create, explore, and manipulate materials in nano-regime. Such materials have chemical, physical, and biological properties that are quite different from their bulk counterparts. For pharmaceutical applications and in order to improve their administration (oral, pulmonary and dermal), the nanocarriers can be spread into microparticles. These supramolecular associations can also modulate the kinetic releases of drugs entrapped in the nanoparticles. Different strategies to produce these hybrid particles and to optimize the release kinetics of encapsulated drugs are discussed in this review. Keywords: pharmaceutical nanotechnologies; microparticles; microspheres; vectors; solubility; permeability; dosage form; administration routes; drug targeting; release; nanoemulsion; trojan 1. Introduction Nowadays, nanotechnology is a multidisciplinary scientific field that is currently undergoing a large technological development. Nano-enhanced medicines a