Treatment outcomes and plasma level of ritonavir-boosted lopinavir monotherapy among HIV-infected patients who had NRTI and NNRTI failure 英文参考文献.docVIP

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Treatment outcomes and plasma level of ritonavir-boosted lopinavir monotherapy among HIV-infected patients who had NRTI and NNRTI failure 英文参考文献.doc

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Treatment outcomes and plasma level of ritonavir-boosted lopinavir monotherapy among HIV-infected patients who had NRTI and NNRTI failure 英文参考文献

AIDS Research andTherapy BioMedCentral Research Open Access Treatment outcomes andplasma level ofritonavir-boosted lopinavir monotherapy among HIV-infected patients whohad NRTI andNNRTI failure Weerawat Manosuthi* ,Sasisopin Kiertiburanakul2, Wannarat Amornnimit1,Wisit Prasithsirikul1,Supeda Thongyen1, SamruayNilkamhang1,KiatRuxrungtham3,4andSomnuekSungkanuparph2 1,2 Address: 1Bamrasnaradura Infectious Diseases Institute, Ministry ofPublic Health, Nonthaburi, 11000, Thailand, 2Faculty ofMedicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 3TheHIVNetherlands-Australia-Thailand (HIV-NAT) Research Collaboration, Thai RedCross AIDSResearch Centre, Bangkok, Thailand and 4Department ofMedicine, Faculty ofMedicine, Chulalongkorn University, Bangkok, Thailand E-mail: Weerawat Manosuthi* -drweerawat@; Sasisopin Kiertiburanakul -sasisopin@; Wannarat Amornnimit -wannarata@; Wisit Prasithsirikul -drwisit_p@; Supeda Thongyen -supeda_t@; Samruay Nilkamhang -samruay-nil@; Kiat Ruxrungtham -rkiat@; Somnuek Sungkanuparph -ssungkanuparph@ *Corresponding author Published: 23December 2009 Received: 30October 2009 Accepted: 23December 2009 AIDSResearch andTherapy 2009, 6:30 doi: 10.1186/1742-6405-6-30 This article isavailable from: /content/6/1/30 ?2009Manosuthi etal;licensee BioMed Central Ltd. ThisisanOpenAccess article distributed undertheterms oftheCreative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use,distribution, andreproduction inanymedium, provided theoriginal workisproperly cited. Abstract Background: Different strategies of ritonavir-boosted lopinavir monotherapy have been explored; however, data regarding salvage therapy among HIV-infected patients who failed nucleoside reverse transcriptase inhibitor (NRTI) and non-nucleoside reverse transcriptase inhibitor (NNRTI) is still limited. Methods: A prospective study was conducted among HIV-infected patients who failed NNRTI- based antiretroviral therapy with