Tumour necrosis factor-dependent inflammatory cartilage destruction 英文参考文献.docVIP

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Tumour necrosis factor-dependent inflammatory cartilage destruction 英文参考文献.doc

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Tumour necrosis factor-dependent inflammatory cartilage destruction 英文参考文献

Available online /supplements/9/S3 Arthritis Research Therapy Volume 9 Suppl 3, 2007 6th Global Arthritis Research Network (GARN) Meeting Zurich, Switzerland 10-13 May 2007 Published online: 19 October 2007 These abstracts are available online at /supplements/9/S3 ? 2007 BioMed Central Ltd Arthritis models P2 Combined anti-inflammatory tritherapy using a novel small interfering RNA lipoplex successfully prevents and cures mice of arthritis P1 IL-21 modulates cytokine levels in murine collagen-induced arthritis and contributes to disease pathology M Khoury1,2, V Escriou3,4,5,6, A Galy7,8, R Yao7,8, C Largeau3,4,5,6, D Scherman3,4,5,6, C Jorgensen1,2,9, F Apparailly1,2 DA Young, M Hegen, H Ma, L Napierata, J Lamothe, M Senices, L Lowe, M Collins, C Nickerson-Nutter Inflammation, Wyeth Research, Cambridge, MA, USA Arthritis Research Therapy 2007, 9(Suppl 3):P1 (doi: 10.1186/ar2227) 1Inserm, U 844, INM, H?pital Saint Eloi, Montpellier, France; 2Université Montpellier1, UFR de Médecine, Montpellier, France; 3Inserm, U 640, Paris, France; 4CNRS, UMR8151, Paris, France; 5Université Paris Descartes, Faculté de Pharmacie, Paris, France; 6Ecole Nationale Supérieure de Chimie de Paris, Paris, France; 7Inserm, U 790, Genethon, Evry, France; 8Université Paris-Sud 11, Orsay, France; 9CHU Lapeyronie, service Immuno-Rhumatologie, Montpellier, France Arthritis Research Therapy 2007, 9(Suppl 3):P2 (doi: 10.1186/ar2228) Background IL-21 is secreted by activated T cells and modulates immune cell functions with both proinflammatory and anti-inflam- matory effects. IL-21 receptor (IL-21R), homologous to IL-2Rβ and IL-4Rα, associates with the gamma common chain upon ligand binding. It was recently described that IL-21R is overexpressed in the inflamed synovial membrane and on leucocytes of rheumatoid arthritis patients. Objective Previously we have shown that blockade of the IL-21 pathway with soluble IL-21R-Fc resulted in a reduction of clinical signs of