Unraveling regulatory networks in plant defense using microarrays 英文参考文献.docVIP

/2001/2/1/reviews/1001.1 Minireview Unraveling regulatory networks in plant defense using microarrays Owen Rowland and Jonathan DG Jones Address: Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Colney Lane, Norwich, NR4 7UH, UK. Correspondence: Jonathan DG Jones. E-mail: jonathan.jones@bbsrc.ac.uk Published: 3 January 2001 GenomeBiology 2001, 2(1):reviews1001.1–1001.3 The electronic version of this article is the complete one and can be found online at /2001/2/1/reviews/1001 ? BioMed Central Ltd. (Print ISSN 1465-6906; Online ISSN 1465-6914) Abstract DNA microarrays are being used to comprehensively examine gene expression networks during the plant defense response that is triggered when a plant encounters a pathogen or an elicitor molecule. In addition to identifying new genes induced during defense, these studies are providing new insights into the complex pathways governing defense gene regulation. Plants induce an array of defenses in response to pathogen attack [1]. 2or example, a rapid defense mechanism known as the hypersensitive response is often induced upon recog- nition of a pathogen-derived molecule [2]. The hypersensi- tive response results in rapid death of plant cells at the site of infection, which probably serves to prevent pathogen spread. Subsequent to the hypersensitive response, a long- lasting enhanced resistance develops throughout the plant, termed systemic acquired resistance (SAR) [3]. SAR confers resistance not only to secondary challenge by the initial infecting pathogen, but also to a wide range of nor- mally virulent pathogens. SAR is associated with increased levels of salicylic acid (SA), both at the infection site and systemically. SA is necessary and sufficient for SAR: appli- cation of SA onto plants can induce SAR, whereas expres- sion of an SA-oxidizing enzyme, salicylate hydroxylase, suppresses SAR. SAR is also co