Use of antipsychotics and benzodiazepines in patients with psychiatric emergencies Results of an observational trial 英文参考文献.docVIP

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Use of antipsychotics and benzodiazepines in patients with psychiatric emergencies Results of an observational trial 英文参考文献.doc

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Use of antipsychotics and benzodiazepines in patients with psychiatric emergencies Results of an observational trial 英文参考文献

BMC Psychiatry BioMedCentral Research article Open Access Use of antipsychotics and benzodiazepines in patients with psychiatric emergencies: Results of an observational trial Stefan Wilhelm*, Alexander Schacht? and Thomas Wagner? Address: Medical Department, Lilly Deutschland GmbH, Saalburgstra?e 153, Bad Homburg, Germany Email: Stefan Wilhelm* - wilhelm_stefan@; Alexander Schacht - schacht_alexander@; Thomas Wagner - wagnertt@ * Corresponding author ?Equal contributors Published: 22 July 2008 Received: 23 February 2007 Accepted: 22 July 2008 BMC Psychiatry 2008, 8:61 doi:10.1186/1471-244X-8-61 This article is available from: /1471-244X/8/61 ? 2008 Wilhelm et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Conventional antipsychotics augmented with benzodiazepines have been the standard acute treatment for psychiatric emergencies for more than 50 years. The inability of patients to give informed consent limits randomised, controlled studies. This observational study on immediate therapy for aggression and impulse control in acutely agitated patients (IMPULSE) evaluated the short-term effectiveness and tolerability of atypical and typical antipsychotic medications (AP) in a non-interventional setting. Methods: This was a comparative, non-randomised, prospective, open-label, observational study. Treatment over the first 5 days was classified according to whether any olanzapine, risperidone, or haloperidol was included or not. Documentations (PANSS-excited component, CGI-aggression, CGI-suicidality, tranquilisation score) were at baseline (day 1) and days 2–6 after start of AP. Results: During the short treatment-period, PANSS-EC and CGI-aggression