郭颖杰《药 理 学》绪论.pptVIP

27) High attrition To turn out just one to two products requires about a hundred discovery projects or approaches, involving upwards of 7 million compound tests in early screening assays. This level of screening produces about a thousand compounds with some of the criteria we are looking for. Follow-up molecular design and sophisticated biological testing narrows the number of development candidates. Once safety is confirmed in animal studies, compounds are advanced into human clinical trials where efficacy, safety and toleration are confirmed. 药 理 学 郭颖杰 副教授 E-mail: guoyingjie@jlu