A role for Numb in p53 stabilization.docVIP

Minireview A role for Numb in p53 stabilization Stephanie Carter and Karen H Vousden Address: The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. Correspondence: Karen H Vousden. Email: k.vousden@beatson.gla.ac.uk Published: 9 May 2008 Genome Biology 2008, 9:221 (doi:10.1186/gb-2008-9-5-221) The electronic version of this article is the complete one and can be found online at /2008/9/5/221 ? 2008 BioMed Central Ltd Abstract The cell-fate determinant Numb has recently been shown to help activate the tumor suppressor protein p53. Loss of Numb