原创力文档ABCG2V-ATPase was associated with the drug resistance and tumor metastasis of esophageal squamous cancer cells.docVIP
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ABCG2V-ATPase was associated with the drug resistance and tumor metastasis of esophageal squamous cancer cells
Huangetal.DiagnosticPathology2012,7:180
/content/7/1/180
RESEARCH
OpenAccess
ABCG2/V-ATPasewasassociatedwiththedrug
resistanceandtumormetastasisofesophageal
squamouscancercells
LijunHuang1?,QiangLu1?,YongHan1?,ZheLi2,ZhipeiZhang1*andXiaofeiLi1*
Abstract
Background:ATP-bindingcassettesub-familyGmember2(ABCG2)isaproteinthatinhumansisencodedbythe
ABCG2gene.ABCG2participatesineffluxofmanychemotherapeuticagents.ABCG2isoftenexpressedin
hematopoieticprogenitororstemcells.Vacuolar-H+?ATPase(V-ATPase)playsakeyroleinadjustingand
maintainingintracellularpHandinregulatingthedrugtoleranceofcells.TheTNMClas
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