Apoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone.docVIP

Lamounieretal.DiabetologyMetabolicSyndrome2013,5:1 /content/5/1/1 DIABETOLOGY METABOLIC SYNDROME RESEARCH OpenAccess Apoptosisrateandtranscriptionalresponseof pancreaticisletsexposedtothePPARgamma agonistPioglitazone RodrigoNLamounier1,2?,CassioNCoimbra1,3?,PeterWhite2,FlaviaLCostal1,LeonardoSOliveira1,3, DanielGiannella-Neto4,KlausHKaestner2*?andMariaLúciaCorrêa-Giannella1*? Abstract Toexplorethemolecularpathwaysunderlyingthiazolidinedioneseffectsonpancreaticisletsinconditions mimickingnormo-andhyperglycemia,apoptosisrateandtranscriptionalresponsetoPioglitazoneatboth physiologicalandsupra