Assay Format as a Critical Success Factor for Identification of Novel Inhibitor Chemotypes of Tissue-Nonspecific Alkaline Phosphatase from High-Throughput Screening.docVIP

Molecules 2010, 15, 3010-3037; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Assay Format as a Critical Success Factor for Identification of Novel Inhibitor Chemotypes of Tissue-Nonspecific Alkaline Phosphatase from High-Throughput Screening Thomas D.Y. Chung 1, Eduard Sergienko 1 and José Luis Millán 2,* 1 Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA; E-Mails: tchung@ (T.D.Y.C.); esergien@ (E.S.) 2 Sanford Children’s Health Research Center, Sanford-Burnham Medical Research Ins