Assessing causal relationships in genomics From Bradford-Hill criteria to complex gene-environment interactions and directed acyclic graphs.docVIP

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2017-05-15 发布于上海
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Assessing causal relationships in genomics From Bradford-Hill criteria to complex gene-environment interactions and directed acyclic graphs.doc

Assessing causal relationships in genomics From Bradford-Hill criteria to complex gene-environment interactions and directed acyclic graphs

Genelettietal.EmergingThemesinEpidemiology2011,8:5 /content/8/1/5 EMERGINGTHEMES IN EPIDEMIOLOGY METHODOLOGY OpenAccess Assessingcausalrelationshipsingenomics: FromBradford-Hillcriteriatocomplex gene-environmentinteractionsanddirected acyclicgraphs SaraGeneletti1*,ValentinaGallo2,3,MiquelPorta4,MuinJKhoury5andPaoloVineis6,7 Abstract Observationalstudiesofhumanhealthanddisease(basic,clinicalandepidemiological)arevulnerableto methodologicalproblems-suchasselectionbiasandconfounding-thatmakecausalinferencesproblematic.Gene- diseaseassociationsarenoexception,astheyarecommonlyinvestigatedusingobser

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Assessing causal relationships in genomics From Bradford-Hill criteria to complex gene-environment interactions and directed acyclic graphs.docVIP