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Arsenic, asbestos and radon emerging players in lung tumorigenesis
Hubauxetal.EnvironmentalHealth2012,11:89
/content/11/1/89
REVIEW
OpenAccess
Arsenic,asbestosandradon:emergingplayersin
lungtumorigenesis
RolandHubaux*?,DaianaDBecker-Santos?,KateySSEnfield,StephenLam,WanLLamandVictorDMartinez
Abstract
Thecauseoflungcancerisgenerallyattributedtotobaccosmoking.Howeverlungcancerinneversmokers
accountsfor10to25%ofalllungcancercases.Arsenic,asbestosandradonarethreeprominentnon-tobacco
carcinogensstronglyassociatedwithlungcancer.Exposuretotheseagentscanleadtogeneticandepigenetic
alterationsintumorgenomes,impactinggenesandpathwaysinvolvedinlungcancerdevelopment.Mor
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