Statin treatment of osteoporosis Progress.docVIP

Statin treatment of osteoporosis Progress [Keywords:] statins, osteoporosis, drug treatment Osteoporosis (osteoporosis, OP) is a disease involving multiple disciplines. In particular, the 21st century, human life extension and the aging population growing, the incidence of osteoporotic fracture rate increased significantly, with fractures and complications, disability and mortality are rising in the elderly poses a great threat, has caused the World Health Organization and national medical attention. In recent years, studies have shown that statins can promote rodent animals, bone formation and increase bone density function. medical community highly concerned about the drug began to osteoporotic fractures in the application of research, is that statins are 3-hydroxy 3-methyl coenzyme A reductase inhibitors, cholesterol synthesis by inhibiting the rate-limiting enzyme in the chain of reductase to reduce cholesterol synthesis, lowering cholesterol and is widely used in clinical prevention of cardiovascular disease. At the same time, statins also can activate osteoblasts, promote bone anabolic effect, and different concentration dose anabolic effect on bone is different, this feature for the clinical treatment of osteoporotic fractures provides a new approach [1]. are already a lot of research on statin treatment of osteoporosis and reduce fracture risk of elderly mechanism to report, but many studies also reported the opposite. is to present statin treatment of osteoporosis research reviewed in the paper. 1 statins reduce fracture risk clinical study UK General Practitioners Research Database data show that statin use associated with fracture risk was significantly reduced, are using statins in patients, this correlation is most obvious, and even those who have only used the short period Patients have a role, also found that fibrates or other lipid-lowering drug use, and not reduce the risk of fracture. New Jersey in the United States population-based cas