Bone-seeking TRAP conjugates surprising observations and their implications on the development of gallium-68-labeled bisphosphonates.docVIP

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Bone-seeking TRAP conjugates surprising observations and their implications on the development of gallium-68-labeled bisphosphonates.doc

Bone-seeking TRAP conjugates surprising observations and their implications on the development of gallium-68-labeled bisphosphonates

Notnietal.EJNMMIResearch2012,2:13 /content/2/1/13 SHORT COMMUNICATION OpenAccess Bone-seekingTRAPconjugates:surprising observationsandtheirimplicationsonthe developmentofgallium-68-labeled bisphosphonates JohannesNotni1*,JanPlutnar2andHans-JürgenWester1 Abstract Background:Bisphosphonatespossessstrongaffinitytobone. 99mTcbisphosphonatecomplexesarewidelyused forbonescintigraphy.Forpositronemissiontomography(PET)boneimaging,Ga-68-basedPETtracersbasedon bisphosphonatesarehighlydesirable. Findings:Twotrimericbisphosphonateconjugatesofthetriazacyclononane-phosphinate(TRAP)chelatorwere synthes

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Bone-seeking TRAP conjugates surprising observations and their implications on the development of gallium-68-labeled bisphosphonates.docVIP