慢性高原病患者脑血管收缩反应与血浆内皮素及其受体、内皮型一氧化氮合酶关系.pdfVIP

青海大学硕士学位论文 Abstract Study on the cerebral vasoconstriction reactions and plasma levels of ETBR,ET-1, eNOS concentration in patients with chronic mountain sickness Abstract Objective: This study intends to identify the associations of the cerebral vasoconstriction in patients with chronic high altitude disease (Cerebrovascular reactivity, CVR), in order to evaluate the differences in CMS patients and healthy control populations brain vascular contractile reactivity changes, this study simultaneous determinate the changes of the endothelin and its receptor, eNOs levels in the plasma, our study aims to investigate the brain reservation capacities in chronic mountain sickness patients. Methods: The transcranial Doppler ultrasound (Transcranial Doppler, Ultrasoiund, and TCD) were been used and the carbon dioxide (CO2) analyze methods were also analyzed to detect the CVR variances at the same time the ELISA (enzyme-linked immunosorbent assay) approaches were also utilized to detect the endothelin and endothelin receptor B and the endothelial NOS levels in serum of the CMS and healthy control subjects. Results: The CMS patients have the CVR (3.84 ±3.01) and CVRI (3.50 ±2.85) and both of them were lower than healthy people CVR (6.39 ±6.87) and CVRI (7.13 ±7.54) (p0.05); eNOS was 31.47 ±10.78pg/ul in CMS and healthy group is 38.28 ±13.89pg/ul, no statistical significance p0.05 differences; ET-1 was 42.04±20.29pg/ul in CMS and 41.89 ± 17.87pg/ul in healthy control, with p0.05; however, ET receptor concentration is 386.07 ±281.57ug/ul in CMS and 312.30 ±238.07ug/ul, in healthy control with p0.05 have the statistically significance. Conclusion: Cere