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Contribution of uric acid to cancer risk, recurrence, and mortality
Finietal.ClinicalandTranslationalMedicine2012,1:16
/content/1/1/16
REVIEW
OpenAccess
Contributionofuricacidtocancerrisk,
recurrence,andmortality
MehdiAFini1,AnthonyElias2,RichardJJohnson3andRichardMWright4*
Abstract
Tworiskfactorsforthedevelopmentandprogressionofcancersthatareamenabletolifestylemodificationare
chronicinflammationandthemetabolicsyndrome.Thisreviewproposestwonewtargetsthatmaymechanistically
integrateinflammationandmetabolicsyndrome,havebeenlargelyignored,andareknowntobedruggable.
Recentevidencehasdemonstratedthatelevatedserumuricacid(hyperuricemia)isassociatedwithexcesscancer
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