Does fluid loading influence measurements of intestinal permeability.docVIP

Available online /content/9/3/R234 Research Open Access Vol 9 No 3 Does fluid loading influence measurements of intestinal permeability? Ilkka Parviainen1, Jukka Takala2 and Stephan M Jakob3 1Consultant, Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland 2Professor, Department of Intensive Care Medicine, University Hospital Bern, Bern, Switzerland 3Consultant, Department of Intensive Care Medicine, University Hospital Bern, Bern, Switzerland Corresponding author: Ilkka Parviainen, ilkka.parviainen@kuh.fi Received: 9 Feb 2005 Revisions requested: 24 Feb 2005 Revisions received: 25 Feb 2005 Accepted: 3 Mar 2005 Published: 21 Mar 2005 Critical Care 2005, 9:R234-R237 (DOI 10.1186/cc3511) This article is online at: /content/9/3/R234 ? 2005 Parviainen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Urinary recovery of enterally administered probes is used as a clinical test of intestinal mucosal permeability. Recently, evidence has been provided that the recovery of some but not all sugar probes is dependent on the amount of diuresis and renal function. The aim of this study was to assess the effect of fluid loading on the urinary recovery of sugar probes in healthy volunteers. following 3 hours. The sugar concentrations were measured in 5-hour urine samples period. Results Fluid loading increased urine production and urinary recovery of xylose. Fluid loading did not influence the urinary recovery of 3-OMG, L-rhamnose, or lactulose. Neither the ratio nor the 3-OMG/rhamnose ratio lactulose/rhamnose changed. Methods In a cross-over study, 10 healthy volunteers ingested 100 ml of a solution containing 0.2 g of 3-O-methyl-D-glucose (3