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Effects of ambient air pollution on functional status in patients with chronic congestive heart failure a repeated-measures study.doc

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Effects of ambient air pollution on functional status in patients with chronic congestive heart failure a repeated-measures study

Environmental Health BioMedCentral Research Open Access Effects of ambient air pollution on functional status in patients with chronic congestive heart failure: a repeated-measures study Gregory A Wellenius*1, Gloria Y Yeh2, Brent A Coull3, Helen H Suh4, Russell S Phillips2 and Murray A Mittleman1 Address: 1Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA, 2Division of General Medicine and Primary Care, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA, 3Department of Biostatistics, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA and 4Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA Email: Gregory A Wellenius* - gwelleni@; Gloria Y Yeh - gyeh@; Brent A Coull - bcoull@; Helen H Suh - hsuh@; Russell S Phillips - rphillips@; Murray A Mittleman - mmittlem@ * Corresponding author Published: 10 September 2007 Received: 21 May 2007 Accepted: 10 September 2007 Environmental Health 2007, 6:26 doi:10.1186/1476-069X-6-26 This article is available from: /content/6/1/26 ? 2007 Wellenius et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Studies using administrative data report a positive association between ambient air pollution and the risk of hospitalization for congestive heart failure (HF). Circulating levels of B- type natriuretic peptide (BNP) are directly associated with cardiac hemodynamics and symptom severity in patients with HF and, therefore, serves as a marker of functional status. We tested the hypothesis that BNP levels would be po