Effects of dopexamine on the intestinal microvascular blood flow and leucocyte activation in a sepsis model in rats.docVIP
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Effects of dopexamine on the intestinal microvascular blood flow and leucocyte activation in a sepsis model in rats
Available online /content/10/4/R117
Research
Open Access
Vol 10 No 4
Effects of dopexamine on the intestinal microvascular blood flow
and leucocyte activation in a sepsis model in rats
Jürgen Birnbaum1, Edda Klotz1, Claudia D Spies1, Bj?rn Lorenz1, Patrick Stuebs1,
Ortrud Vargas Hein1, Matthias Gründling2, Dragan Pavlovic2, Taras Usichenko2, Michael Wendt2,
Wolfgang J Kox1 and Christian Lehmann2
1Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow Klinikum, Charité-University Medicine
Berlin, Charitéplatz 1, 10117 Berlin, Germany
2Department of Anesthesiology and Intensive Care Medicine, Ernst-Moritz-Arndt-University Greifswald, Friedrich L?ffler-Str. 23 B, 17475 Greifswald,
Germany
Corresponding author: Jürgen Birnbaum, juergen.birnbaum@charite.de
Received: 16 Feb 2006 Revisions requested: 31 Mar 2006 Revisions received: 19 Jul 2006 Accepted: 7 Aug 2006 Published: 7 Aug 2006
Critical Care 2006, 10:R117 (doi:10.1186/cc5011)
This article is online at: /content/10/4/R117
? 2006 Birnbaum et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction Dopexamine may be a therapeutic option to
improve hepatosplanchnic perfusion in sepsis. To investigate
this possibility, we administered dopexamine in an experimental
sepsis model in rats.
Results One hour after endotoxin challenge, IMBF decreased
significantly in LPS group to 51% compared with baseline (P
0.05). In DPX group (endotoxin plus dopexamine) we found
IMBF values significantly higher than those in LPS group
(approximately at the level of controls). The impaired FCD
following endotoxin challenge was improved by dopexamine in
the longitudinal muscle layer (+33% in DPX group ve
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