Effects of a multi-herbal extract on type 2 diabetes.docVIP

Yeoetal.ChineseMedicine2011,6:10 /content/6/1/10 RESEARCH OpenAccess Effectsofamulti-herbalextractontype2 diabetes JiyoungYeo,Young-MiKang,Su-InCho,Myeong-HoJung* Abstract Background:Anaqueousextractofmulti-hypoglycemicherbsofPanaxginsengC.A.Meyer,Puerarialobata, DioscoreabatatasDecaisne,Rehmanniaglutinosa,AmomumcadamomumLinné,PoncirusfructusandEvodia officinaliswasinvestigatedforitsanti-diabeticeffectsincellandanimalmodels. Methods:ActivitiesofPPARgagonist,anti-inflammation,AMPKactivatorandanti-ERstressweremeasuredincell modelsandindb/dbmice(ageneticanimalmodelfortype2diabetes). Results:WhiletheextractstimulatedPPARg-dependentluciferaseactivityandactivatedAMPKinC2C12cells,it inhibitedTNF-a-stimulatedIKKb/NFkBsignalingandattenuatedERstressinHepG2cells.Thedb/dbmicetreated withtheextractshowedreducedfastingbloodglucoseandHbA1c levels,improvedpostprandialglucoselevels, enhancedinsulinsensitivityandsignificantlydecreasedplasmafreefattyacid,triglycerideandtotalcholesterol. Conclusion:Theaqueousextractofthesesevenhypoglycemicherbsdemonstratedmanytherapeuticeffectsfor thetreatmentoftype2diabetesincellandanimalmodels. Background While traditional formulae are often prescribed, their Causedbycomplexinteractionsofmultiplefactors,dia- efficacyhasyettobeinvestigated;recently,anti-diabetic betes mellitus type 2 (type 2 diabetes) is characterized multi-herbalformulaewerestudiedandreported[6,7]. by decreased secretion of insulin by the pancreas and Thepresentstudyreportsanewanti-diabeticformula resistance totheaction ofinsulin invarious tissues (eg consisting of seven herbs, namely hypoglycaemic cadi- muscle, liver, adipose), leading to impaired glucose dates including Panax ginseng C.A.Meyer, Pueraria uptake [1]. Management of type 2 diabetes usually lobata, Dioscorea batatas Decaisne, Rehmannia gluti- begins with change of diet and exercise [2] and most nosa [8], Amomum cadamomum Linné [9] , Poncirus patients ultimately require pharmacotherapy, such as fruc