Effect of tylosin on dogs with suspected tylosin-responsive diarrhea a placebo-controlled, randomized, double-blinded, prospective clinical trial.docVIP

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Effect of tylosin on dogs with suspected tylosin-responsive diarrhea a placebo-controlled, randomized, double-blinded, prospective clinical trial.doc

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Effect of tylosin on dogs with suspected tylosin-responsive diarrhea a placebo-controlled, randomized, double-blinded, prospective clinical trial

Kilpinenetal.ActaVeterinariaScandinavica2011,53:26 /content/53/1/26 RESEARCH OpenAccess Effectoftylosinondogswithsuspected tylosin-responsivediarrhea:aplacebo-controlled, randomized,double-blinded,prospective clinicaltrial SusanneKilpinen1*,ThomasSpillmann1,PernillaSyrj?2,TeresaSkrzypczak3,MariaLouhelainen1and EliasWestermarck1 Abstract Background:The macrolid antibiotic tylosin has been widely used to treat canine chronic diarrhea, although its efficacy is based on anecdotal reports and experimental studies in dogs and not on strong scientific evidence. The term tylosin-responsive diarrhea (TRD) refers to diarrheal disorders responding to tylosin therapy within a few days. In TRD, the stool remains normal as long as tylosin treatment continues, but diarrhea reappears in many dogs within weeks after discontinuation. The aim of our trial was to assess the effect of tylosin on fecal consistency compared with aplacebo treatment in dogs with suspected TRD and additionally to establish whether tylosin in dogs with recurrent diarrhea is as effective as empirical studies and anecdotal reports suggest. Methods:Subjects comprised 71 client-owned dogs that, according to the owners, had previously been treated successfully with tylosin due to recurrent diarrhea of unknown etiology. At the initial examination, where there were no signs of diarrhea, the dogs were randomly assigned in a 2:1 ratio to a tylosin or placebo group. During a two-month follow-up the owners evaluated the fecal consistency according to previously published guidelines. When diarrhea recurred, either tylosin (25 mg/kg q 24 h, 7 days) or placebo treatment was initiated orally. Treatment outcome was evaluated as the mean of fecal consistency scores assigned during the last three days of the treatment period. To test for differences between the tylosin and placebo group in the proportion of responders, Pearson’s Chi-squared test and Fisher’s exact test were applied. Results:Sixty-onedogsmettheselectioncriteria