Effect of vitamin D on insulin resistance and anthropometric parameters in Type 2 diabetes; a randomized double-blind clinical trial.docVIP

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Effect of vitamin D on insulin resistance and anthropometric parameters in Type 2 diabetes; a randomized double-blind clinical trial.doc

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Effect of vitamin D on insulin resistance and anthropometric parameters in Type 2 diabetes; a randomized double-blind clinical trial

Heshmatetal.DARUJournalofPharmaceuticalSciences2012,20:10 /content/20/1/10 RESEARCH ARTICLE OpenAccess EffectofvitaminDoninsulinresistanceand anthropometricparametersinType2diabetes;a randomizeddouble-blindclinicaltrial RaminHeshmat,OzraTabatabaei-Malazy*,ShabnamAbbaszadeh-Ahranjani,SamimehShahbazi, GhazalKhooshehchin,FathemehBandarianandBagherLarijani Abstract Backgroundthepurposeofthestudy:Prevalenceoftype2diabetesmellitus(T2DM)isincreasingworldwide. Toreduceitsriskandprogression,preventivestrategiesareneeded.VitaminsupplementationsuchasvitaminDis oneofthestrategies.ThisstudywasdesignedtoinvestigatetheeffectofinjectionofvitaminDoninsulin resistanceandanthropometricparametersinT2DM. Methods:Thisrandomizeddouble-blindclinicaltrialwasconductedwith42diabeticpatientsintwogroups; interventiongroupwithsingleintramuscularinjectionof300,000InternationalUnit(IU)ofvitaminD3andthe placebogroup.Afterrecordingdemographicandanthropometricfactors(waistcircumference,bloodpressureand bodymassindex),fastingbloodsampleswastakenformeasurementofbloodglucose,25-hydroxyvitaminD3(25- OHD3),insulin,glycosylatedhemoglobinA1c(HbA1c)andestimationofHomeostasisModelAssessmentIndex (HOMA)intwotimes;beforestudyandafterthreemonths. Results:Twogroupshadsimilarbaselinecharacteristics(eachgroup=21subjects).ThreemonthsaftervitaminD injection,HbA1c,anthropometricfactorsandHOMAindexininterventiongroupstayedconstant,however,serum 25-OHD3wassignificantlyincreased(p=0.007). Conclusion:Thepresentdataisnotconvincingandfurtherstudieswithlargesamplesizesareneededtoshow thedefiniteeffectofinjectionofvitaminDoncontrolofdiabetesanditsrisk. Keywords:Diabetesmellitus,VitaminD,Bodymassindex,Insulinresistance Introduction mineral.VitaminDisessentialfornormalinsulinsecre- Prevalence of type 2 diabetes mellitus (T2DM) is in- tion in response to glucose and also for maintenance of creasing worldwide. Nowadays over 360 million people glucose tolerance [3-6]. In a study performed on 126 are suffering from diabetes and