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Embolization of Cyanoacrylate glue in systemic circulation in a case of hepatocellular carcinoma an autopsy report.doc

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Embolization of Cyanoacrylate glue in systemic circulation in a case of hepatocellular carcinoma an autopsy report

Diagnostic Pathology BioMedCentral Case Report Open Access Embolization of Cyanoacrylate glue in systemic circulation in a case of hepatocellular carcinoma: an autopsy report Kirti Gupta*1, Rakesh K Vasishta1, Usha Dutta2, Rakesh K Kochhar2 and Kartar Singh2 Address: 1Department of Histopathology, Post Graduate Institute of Medical Education and Research, (PGIMER), Chandigarh, India and 2Department of Gasteroenterology, Post Graduate Institute of Medical Education and Research, (PGIMER), Chandigarh, India Email: Kirti Gupta* - kirtigupta10@yahoo.co.in; Rakesh K Vasishta - r_vasishta@; Usha Dutta - ushadutta@; Rakesh K Kochhar - dr_kochhar@; Kartar Singh - kartarsinghpgi@ * Corresponding author Published: 9 December 2009 Received: 15 September 2009 Accepted: 9 December 2009 Diagnostic Pathology 2009, 4:45 doi:10.1186/1746-1596-4-45 This article is available from: /content/4/1/45 ? 2009 Gupta et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract We report a case of embolism of the sclerosant dye with subsequent formation of foreign-body giant cell reaction within the veins of pulmonary and portal circulation in an autopsy case of hepatocellular carcinoma developing over an underlying primary biliary cirrhosis. Clinical Summary (SMA), anti-liver/kidney microsome antibody (LKM) and anti-mitochondrial antibody (AMA)] were negative. The liver biopsy was deferred in view of persistent deranged coagulation profile. She was started on Azathioprine (50 mg) which had to be stopped after 9 months because of persistent elevation of liver enzymes (aspartate ami- notransferase (AST) - 100 IU/L, alanine transaminase (ALT) - 56 IU/L and alkaline phosphatase (ALP) - 622 IU/ L) sug