Electrotransfer of low doses of plasmid encoding interleukin-10 in gene therapy of collagen-induced arthritis.docVIP

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Electrotransfer of low doses of plasmid encoding interleukin-10 in gene therapy of collagen-induced arthritis.doc

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Electrotransfer of low doses of plasmid encoding interleukin-10 in gene therapy of collagen-induced arthritis

Available online /supplements/4/S1 Meeting abstracts 22nd European Workshop for Rheumatology Research Leiden, The Netherlands 28 February – 3 March 2002 Received: 15 January 2002 Published: 4 February 2002 Arthritis Res 2002, 4 (suppl 1) ? 2002 BioMed Central Ltd (Print ISSN 1465-9905; Online ISSN 1465-9913) Aetiopathogenesis of rheumatic diseases 1 logic effects of VEGF in SSc patients. Serum levels of VEGF were also correlated significantly with disease severity parameters including antitopoisomerase antibodies. These results suggest that therapeutic application of VEGF by either gene transfer or as a recombinant protein might be a novel option in SSc. HIF-1 mediated upregulation of VEGF and VEGF-R in systemic sclerosis (SSc): Imbalance with angiostatic factors suggests VEGF as a novel option for the treatment of ischemia in patients 2 with SSc Comparison of the features of arthroscopic synovial biopsies with biopsy samples obtained at surgery O Distler*, A Scheid?, A Del Rosso?, J Rethage*, M Neidhart*, RE Gay*, U Müller-Ladner§, M Gassmann?, M Matucci-Cerinic?, S Gay* TJM Smeets*, MC Kraan*, E Barge?, MD Smith?, PP Tak* *Ctr Exp Rheum, Zurich, Switzerland ?Inst Physiol Univ Zurich, Zurich, Switzerland ?Dept Med Sect Rheum, Florence, Italy *Academic Medical Center, Amsterdam, The Netherlands ?Leiden University Medical Center, Leiden, The Netherlands §Dept Int Med I, Univ Hosp, Regensburg, Germany ?Repatriation General Hospital, Daw Park, SA, Australia Vascular changes are consistent early findings in patients with SSc and often precede the development of fibrosis. Despite a signifi- cant reduction in the capillary density, there is paradoxically no suf- ficient angiogenesis in the skin of SSc patients. By using a pO2 Objective: Most of the older descriptions of the synovial infiltrate are based on examination of synovial tissue (ST) obtained at surgery. However, ST from end-stage destructive rheumatoid arthrit