Endotoxin neutralization and anti-inflammatory effects of tobramycin and ceftazidime in porcine endotoxin shock.docVIP

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Endotoxin neutralization and anti-inflammatory effects of tobramycin and ceftazidime in porcine endotoxin shock.doc

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Endotoxin neutralization and anti-inflammatory effects of tobramycin and ceftazidime in porcine endotoxin shock

Available online /content/8/1/R35 Open Access Research Endotoxin neutralization and anti-inflammatory effects of tobramycin and ceftazidime in porcine endotoxin shock Gunilla Goscinski1, Miklos Lipcsey2, Mats Eriksson3, Anders Larsson4, Eva Tano5 and Jan Sj?lin6 1MD, Section of Infectious Diseases, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden 2MD, Department of Anesthesiology and Intensive Care, G?vle-Sandviken County Hospital, G?vle, Sweden 3Associate Professor, Section of Anesthesiology Intensive Care, Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden 4Associate Professor, Section of Clinical Chemistry, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden 5Biomedical Scientist, Section of Clinical Microbiology, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden 6Associate Professor, Section of Infectious Diseases, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden Correspondence: Gunilla Goscinski, gunilla.goscinski@medicin.uas.lul.se Received: 2 June 2003 Critical Care 2004, 8:R35-R41 (DOI 10.1186/cc2415) This article is online at /content/8/1/R35 Revisions requested: 11 July 2003 Revisions received: 7 November 2003 Accepted: 25 November 2003 Published: 23 December 2003 ? 2004 Goscinski et al., licensee BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X). This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Introduction Antibiotics used for treatment of severe bacterial infections have been shown to exert effects on the inflammatory response in addition to their antibacterial effects. The aim of the present study was to investigate whether the biological effects of endotoxin in a porcine model could be neutralized by tobramycin, and wh