Evaluation of the Antiproliferative Activity of the Leaves from Arctium lappa by a Bioassay-Guided Fractionation.docVIP

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Evaluation of the Antiproliferative Activity of the Leaves from Arctium lappa by a Bioassay-Guided Fractionation.doc

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Evaluation of the Antiproliferative Activity of the Leaves from Arctium lappa by a Bioassay-Guided Fractionation

Molecules 2012, 17, 1852-1859; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Evaluation of the Antiproliferative Activity of the Leaves from Arctium lappa by a Bioassay-Guided Fractionation Fabio Bahls Machado 1, Rafael Eidi Yamamoto 2, Karine Zanoli 1, Samara Requena Nocchi 1, Cláudio Roberto Novello 3, Ivania Teresinha Albrecht Schuquel 4, Cássia M?nica Sakuragui 5, Heinrich Luftmann 6, Tania Ueda-Nakamura 1, Celso Vataru Nakamura 1 and Jo?o Carlos Palazzo de Mello 1,* 1 Post-Graduate Program in Pharmaceutical Sciences, State University of Maringá, Av. Colombo, 5790, BR-87020-900, Maringá, PR, Brazil; E-Mails: famafarm@.br (F.B.M.); kazanoli@ (K.Z.); samaranocchi@ (S.R.N.); tunakamura@uem.br (T.U.-N.); cvnakamura@uem.br (C.V.N.) 2 Department of Basic Sciences of Health, State University of Maringá, Av. Colombo, 5790, BR-87020-900, Maringá, PR, Brazil; E-Mail: thexuxs@ 3 Department of Pharmacy, State University of Maringá, Av. Colombo, 5790, BR-87020-900, Maringá, PR, Brazil; E-Mail: crnovello@uem.br 4 Department of Chemistry, State University of Maringá, Av. Colombo, 5790, BR-87020-900, Maringá, PR, Brazil; E-Mail: itaschuquel@uem.br 5 Federal University of Rio de Janeiro, Av. Pedro Calmon, 550, BR-21941-901, Rio de Janeiro, RJ, Brazil; E-Mail: cmsakura12@ 6 Organic Chemistry Institute, University of Münster, Münster D-48149, Germany; E-Mail: luftman@uni-muenster.de * Author to whom correspondence should be addressed; E-Mail: mello@uem.br; Tel.: +55-44-3011-4816; Fax: +55-44-3011-5050. Received: 26 November 2011; in revised form: 17 January 2012 / Accepted: 1 February 2012 / Published: 14 February 2012 Abstract: Arctium lappa L. (Asteraceae) is used in folk medicine around the World, and shows several kinds of biological activity, particularly in vitro antitumor activity in different cell lines. This study evaluated the antiproliferative activity of the crude extract, semipurified frac