Evaluation of the Biological Effects of Externally Tunable, Hydrogel Encapsulated Quantum Dot Nanospheres in Escherichia coli.docVIP

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Evaluation of the Biological Effects of Externally Tunable, Hydrogel Encapsulated Quantum Dot Nanospheres in Escherichia coli.doc

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Evaluation of the Biological Effects of Externally Tunable, Hydrogel Encapsulated Quantum Dot Nanospheres in Escherichia coli

Polymers 2011, 3, 1243-1254; doi:10.3390/polym3031243 OPEN ACCESS polymers ISSN 2073-4360 /journal/polymers Article Evaluation of the Biological Effects of Externally Tunable, Hydrogel Encapsulated Quantum Dot Nanospheres in Escherichia coli Somesree GhoshMitra 1, Tong Cai 2, David Diercks 3, Zhibing Hu 2, James Roberts 2, Jai Dahiya 4, Nathaniel Mills 1, DiAnna Hynds 1 and Santaneel Ghosh 4,* 1 Department of Biology, Texas Woman’s University, Denton, TX 76204, USA; E-Mails: sghoshmitra@ (S.G.); NMills@ (N.M.); Dhynds@ (D.H.) 2 Department of Physics, University of North Texas, Denton, TX 76203, USA; E-Mails: tong.cai@ (T.C.); zbhu@ (Z.H.); roberts@ (J.R.) 3 Metallurgical and Materials Engineering Department, Colorado School of Mines, Golden, CO 80401, USA; E-Mail: ddiercks@ (D.D.) 4 Department of Physics and Engineering Physics, Southeast Missouri State University, Cape Girardeau, MO 63701, USA; E-Mail: jndahiya@ (J.D.) * Author to whom correspondence should be addressed; E-Mail: sghosh@; Tel.: +1-573-651-2393; Fax: +1-573-651-2392. Received: 7 June 2011; in revised form: 20 July 2011 / Accepted: 29 July 2011 / Published: 8 August 2011 Abstract: Quantum Dots (QDs) have become an interesting subject of study for labeling and drug delivery in biomedical research due to their unique responses to external stimuli. In this paper, the biological effects of a novel hydrogel based QD nano-structure on E. coli bacteria are presented. The experimental evidence reveals that cadmium telluride (CdTe) QDs that are encapsulated inside biocompatible polymeric shells have reduced or negligible toxicity to this model cell system, even when exposed at higher dosages. Furthermore, a preliminary gene expression study indicates that QD-hydrogel nanospheres do not inhibit the Green Fluorescent Protein (GFP) gene expression. As the biocompatible and externally tunable polymer shells possess the capability to control the QD pa