Evidence for genetic association of RORB with bipolar disorder.docVIP

BMC Psychiatry BioMedCentral Research article Open Access Evidence for genetic association of RORB with bipolar disorder Casey L McGrath1,2, Stephen J Glatt3, Pamela Sklar1, Helen Le-Niculescu4, Ronald Kuczenski5, Alysa E Doyle6, Joseph Biederman6, Eric Mick6, Stephen V Faraone3, Alexander B Niculescu*4 and Ming T Tsuang*5 Address: 1Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA, 2Department of Biology, Indiana University, Bloomington, IN, USA, 3Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA, 4Laboratory of Neurophenomics, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA, 5Department of Psychiatry, UC San Diego, La Jolla, CA, USA and 6Pediatric Psychopharmacology Unit, Massachusetts General Hospital; Psychiatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Email: Casey L McGrath - mcgrath.casey@; Stephen J Glatt - glatts@; Pamela Sklar - sklar@; Helen Le- Niculescu - hlenicul@; Ronald Kuczenski - rkuczenski@; Alysa E Doyle - doylea@; Joseph Biederman - biederman@; Eric Mick - emick1@; Stephen V Faraone - faraones@; Alexander B Niculescu* - anicules@; Ming T Tsuang* - mtsuang@ * Corresponding authors Published: 12 November 2009 Received: 4 March 2009 Accepted: 12 November 2009 BMC Psychiatry 2009, 9:70 doi:10.1186/1471-244X-9-70 This article is available from: /1471-244X/9/70 ? 2009 McGrath et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Bipolar disorder, particularly in children, is characterized by rapid cycling and switching, making circadian clock genes plausible molecular underpinnings for bipolar disorder. We previously rep