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Expansion of antibody reactivity in the cerebrospinal fluid of multiple sclerosis patients – follow-up and clinical implications.doc

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Expansion of antibody reactivity in the cerebrospinal fluid of multiple sclerosis patients – follow-up and clinical implications

Cerebrospinal Fluid Research BioMedCentral Research Open Access Expansion of antibody reactivity in the cerebrospinal fluid of multiple sclerosis patients – follow-up and clinical implications Hela-Felicitas Petereit and Dirk Reske* Address: Department of Neurology, University of Cologne, Kerpener Str. 62, D-50924 Cologne, Germany Email: Hela-Felicitas Petereit - hela.petereit@medizin.uni-koeln.de; Dirk Reske* - dirk.reske@medizin.uni-koeln.de * Corresponding author Published: 27 June 2005 Received: 07 January 2005 Accepted: 27 June 2005 Cerebrospinal Fluid Research 2005, 2:3 doi:10.1186/1743-8454-2-3 This article is available from: /content/2/1/3 ? 2005 Hela-Felicitas and Reske; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: An intrathecal polyspecific antibody response is a well known finding in multiple sclerosis. However, little is known about the evolution of intrathecal antibodies over time and their impact on the disease progress. Therefore, we focused in this study on the intrathecal polyspecific antibody response in multiple sclerosis. Methods: Here we present a follow-up study of 70 patients with multiple sclerosis over 1 to 106 months. Serum and cerebrospinal fluid sample pairs were obtained from 1 to 5 consecutive lumbar punctures. CSF cell count, the IgG index, local IgG synthesis, oligoclonal bands and the antibody index for measles, rubella or varicella zoster were calculated. Results were analysed with regard to clinical characteristics of the patients. Results: Once an intrathecal antibody response was established, it persisted. De novo antibody response against measles virus developed in 7% of the patients between the first and the second spinal tap. In two of