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Expression and function of junctional adhesion molecule-C in human and experimental arthritis.doc

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Expression and function of junctional adhesion molecule-C in human and experimental arthritis

Available online /content/9/4/R65 Research article Open Access Vol 9 No 4 Expression and function of junctional adhesion molecule-C in human and experimental arthritis Gaby Palmer1*, Nathalie Busso2*, Michel Aurrand-Lions3, Dominique Talabot-Ayer1, Véronique Chobaz-Péclat2, Claudia Zimmerli3, Philippe Hammel3, Beat A Imhof3 and Cem Gabay1 1Division of Rheumatology, Department of Internal Medicine, University Hospital, 26 avenue Beau-Séjour, 1211 Geneva 14, Switzerland and Department of Pathology and Immunology, University of Geneva School of Medicine, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland 2Division of Rheumatology, Department of Medicine, University Hospital, Nestlé 05-5029, 1011 Lausanne, Switzerland 3Department of Pathology and Immunology, University of Geneva School of Medicine, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland * Contributed equally Corresponding author: Cem Gabay, cem.gabay@hcuge.ch Received: 9 Mar 2007 Revisions requested: 11 Apr 2007 Revisions received: 11 Jun 2007 Accepted: 5 Jul 2007 Published: 5 Jul 2007 Arthritis Research Therapy 2007, 9:R65 (doi:10.1186/ar2223) This article is online at: /content/9/4/R65 ? 2007 Palmer et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Junctional adhesion molecule-C (JAM-C) is an adhesion molecule involved in transendothelial migration of leukocytes. In this study, we examined JAM-C expression in the synovium and investigated the role of this molecule in two experimental mouse models of arthritis. JAM-C expression was investigated by and immunohistochemistry. The effects of a monoclonal anti-JAM-C antibody were assessed in antigen-induced arthritis (AIA) and K/ BxN serum transfer-induced arthritis. JAM-C was expressed by synovi