Extracellular heat shock protein 70 inhibits tumour necrosis factor-α induced proinflammatory mediator production in fibroblast-like synoviocytes.docVIP

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Extracellular heat shock protein 70 inhibits tumour necrosis factor-α induced proinflammatory mediator production in fibroblast-like synoviocytes.doc

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Extracellular heat shock protein 70 inhibits tumour necrosis factor-α induced proinflammatory mediator production in fibroblast-like synoviocytes

Available online /content/10/2/R41 Research article Open Access Vol 10 No 2 Extracellular heat shock protein 70 inhibits tumour necrosis factor-α induced proinflammatory mediator production in fibroblast-like synoviocytes Xinjing Luo1,2, Xiaoxia Zuo3, Yaou Zhou3, Bing Zhang1, Yongzhong Shi1, Meidong Liu1, Kangkai Wang1, D Randy McMillian4 and Xianzhong Xiao1 1Department of Pathophysiology, Xiangya School of Medicine, Central South University, Xiangya Road, Changsha, Hunan 410008, China 2Department of Laboratory Medicine, Medical College of Taizhou University, Shifu Road, Taizhou, Zhejiang 318000, China 3Department of Rheumatology and Clinical Immunology, Xiangya Hospital, Central South University, Xiangya Road, Changsha, Hunan 410008, China 4Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390-9063, USA Corresponding author: Xiaoxia Zuo, susanzuo@Xianzhong Xiao, xianzhongxiao@ Received: 28 Dec 2007 Revisions requested: 6 Feb 2008 Revisions received: 27 Feb 2008 Accepted: 14 Apr 2008 Published: 14 Apr 2008 Arthritis Research Therapy 2008, 10:R41 (doi:10.1186/ar2399) This article is online at: /content/10/2/R41 ? 2008 Luo et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction It was recently suggested that heat shock protein (HSP)70, an intracellular protein, is a potential mediator of inflammatory disease when it is released into the extracellular compartment. Although elevated HSP70 levels have been identified in rheumatoid arthritis (RA) synovial tissues and RA synovial fluid compared with patients with osteoarthritis and healthy individuals, it remains unclear what role extracellular HSP70 plays in the pa