Expression of bioactive bone morphogenetic proteins in the subacromial bursa of patients with chronic degeneration of the rotator cuff.docVIP

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Expression of bioactive bone morphogenetic proteins in the subacromial bursa of patients with chronic degeneration of the rotator cuff.doc

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Expression of bioactive bone morphogenetic proteins in the subacromial bursa of patients with chronic degeneration of the rotator cuff

Available online /content/8/4/R92 Research article Open Access Vol 8 No 4 Expression of bioactive bone morphogenetic proteins in the subacromial bursa of patients with chronic degeneration of the rotator cuff Jana Neuwirth1, Renée AE Fuhrmann1, Amanda Veit1, Matthias Aurich1, Ilmars Stonans1, Tilo Trommer1, Peter Hortschansky2, Susanna Chubinskaya3 and Juergen A Mollenhauer1,3 1Department of Orthopedics, University of Jena, Klosterlausnitzerstr. 81, D-07607 Eisenberg 2Leibniz Institute for Natural Product Research and Infection Biology, Hans-Kn?ll Institute, Beutenbergstr. 11a, D-07745 Jena 3Department of Biochemistry, Rush University Medical Center, 1653 W. Congress Parkway, Chicago, IL 60612, USA Corresponding author: Juergen A Mollenhauer, juergen.mollenhauer@med.uni-jena.de Received: 10 Oct 2005 Revisions requested: 27 Oct 2005 Revisions received: 7 Apr 2006 Accepted: 24 Apr 2006 Published: 23 May 2006 Arthritis Research Therapy 2006, 8:R92 (doi:10.1186/ar1965) This article is online at: /content/8/4/R92 ? 2006 Neuwirth et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Degeneration of the rotator cuff is often associated with inflammation of the subacromial bursa and focal mineralization of the supraspinatus tendon. Portions of the supraspinatus tendon distant from the insertion site could transform into fibrous cartilage, causing rotator-cuff tears owing to mechanical instability. Indirect evidence is presented to link this pathology to phosphatase in the osteogenic/myogenic cell line C2C12. Topical and differential expression of BMP-2/4 and BMP-7 mRNA and protein was found in bursa tissue. The bioassay of C2C12 cells revealed amounts of active BMP high enough to i