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Familial, structural, and environmental correlates of MRI-defined bone marrow lesions a sibpair study.doc

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Familial, structural, and environmental correlates of MRI-defined bone marrow lesions a sibpair study

Available online /content/8/4/R137 Research article Open Access Vol 8 No 4 Familial, structural, and environmental correlates of MRI-defined bone marrow lesions: a sibpair study Guangju Zhai1,2, James Stankovich3, Flavia Cicuttini4, Changhai Ding1 and Graeme Jones1 1Menzies Research Institute, University of Tasmania, Level 2, Surrey House, 199 Macquarie Street, Hobart, TAS 7000, Australia 2Twin Research and Genetic Epidemiology Unit, St Thomass Hospital, Lambeth Palace Road, London, SE1 7EH, UK 3The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3050, Australia 4Department of Epidemiology and Preventive Medicine, Monash University Medical School, 89 Commercial Road, Alfred Hospital, Melbourne, VIC 3004, Australia Corresponding author: Graeme Jones, g.jones@.au Received: 11 May 2006 Revisions requested: 7 Jun 2006 Revisions received: 13 Jun 2006 Accepted: 3 Aug 2006 Published: 3 Aug 2006 Arthritis Research Therapy 2006, 8:R137 (doi:10.1186/ar2027) This article is online at: /content/8/4/R137 ? 2006 Zhai et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The aim of this study was to estimate the heritability and describe the correlates of bone marrow lesions in knee subchondral bone. A sibpair design was used. T2- and T1- weighted MRI scans were performed on the right knee to assess bone marrow lesions at lateral tibia and femora and medial tibia and femora, as well as chondral defects. A radiograph was taken on the same knee and scored for individual features of osteoarthritis (radiographic osteoarthritis; ROA) and alignment. Other variables measured included height, weight, knee pain, and lower-limb muscle strength. Herit