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Fabrication and in vitro deployment of a laser-activated shape memory polymer vascular stent.doc

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Fabrication and in vitro deployment of a laser-activated shape memory polymer vascular stent

BioMedical Engineering OnLine BioMedCentral Research Open Access Fabrication and in vitro deployment of a laser-activated shape memory polymer vascular stent Géraldine M Baer1,2, Ward Small IV*2, Thomas S Wilson2, William J Benett2, Dennis L Matthews2,3, Jonathan Hartman4 and Duncan J Maitland2 Address: 1Department of Biomedical Engineering, University of California, Davis, California 95616 USA, 2Lawrence Livermore National Laboratory, Livermore, California 94550 USA, 3Department of Applied Science and School of Medicine, University of California, Davis, California 95616 USA and 4Kaiser Permanente Medical Center, Sacramento, CA 95825 USA and Department of Radiology, University of California, Davis, School of Medicine, Sacramento, CA 95817 USA Email: Géraldine M Baer - gmbaer@; Ward Small* - small3@; Thomas S Wilson - wilson97@; William J Benett - benett1@; Dennis L Matthews - matthews1@; Jonathan Hartman - jonathan.hartman@; Duncan J Maitland - maitland1@ * Corresponding author Published: 27 November 2007 Received: 10 May 2007 Accepted: 27 November 2007 BioMedical Engineering OnLine 2007, 6:43 doi:10.1186/1475-925X-6-43 This article is available from: /content/6/1/43 ? 2007 Baer et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Vascular stents are small tubular scaffolds used in the treatment of arterial stenosis (narrowing of the vessel). Most vascular stents are metallic and are deployed either by balloon expansion or by self-expansion. A shape memory polymer (SMP) stent may enhance flexibility, compliance, and drug elution compared to its current metallic counterparts. The purpose of this study was to describe the fabrication of a laser-activated SMP stent and demonstrate pho