Fiber optic bronchoscopy in patients with acute hypoxemic respiratory failure requiring noninvasive ventilation - a feasibility study.docVIP
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Baumannetal.CriticalCare2011,15:R179
/content/15/4/R179
RESEARCH
OpenAccess
Fiberopticbronchoscopyinpatientswithacute
hypoxemicrespiratoryfailurerequiring
noninvasiveventilation-afeasibilitystudy
HansJ?rgBaumann1,2?,HansKlose2?,MarcelSimon1,2,TarikGhadban1,StephanABraune1,JanKHennigs2and
StefanKluge1*
Abstract
Introduction:Noninvasiveventilation(NIV)isastandardprocedureinselectedpatientswithacuterespiratory
failure.Previousstudieshaveusednoninvasiveventilationtoensureadequategasexchangeduringfiberoptic
bronchoscopyinspontaneouslybreathinghypoxemicpatients,thusavoidingendotrachealintubation.However,it
isunknownwhetherbronchoscopycanbeperformedsafelyinpatientswithacutehypoxemicrespiratoryfailure
alreadyinneedofNIVpriortothedecisionforbronchoscopy.
Methods:Weprospectivelyinvestigated40consecutive,criticallyill,adultpatientswithacutehypoxemic
respiratoryfailure(14women,26men,age61±15years,partialpressureforoxygen/fractionofinspiredoxygen
(PaO2/FiO2)300undernoninvasiveventilation,SimplifiedAcutePhysiologyscores(SAPSII)47±9.9points).All
patientsrequirednoninvasiveventilationpriortothedecisiontoperformbronchoscopy(median10.5h;range2.2
to114).Bloodgases,heartrate,bloodpressureandventilationweremonitoredbefore,duringandupto120
minutesafterbronchoscopy.
Results:Bronchoscopycouldbecompletedinallpatientswithoutsubsequentcomplications.Oxygensaturation
fellto90%intwopatients(5%),andthelowestvalueduringtheprocedurewas84%.ThemeanPaO2/FiO2ratio
improvedfrom176±54atbaselineto240±130(P0.001)attheendofbronchoscopyand210±79after120
minutes.Thetransientmeanpartialpressureofcarbondioxideinthearterialblood(PaCO2)increasewas9.4±8.1
mmHg.Fourpatients(10%)requiredendotrachealintubationduringthefirsteighthoursaftertheprocedure.
Bronchoalveolarlavageyieldeddiagnosticinformationin26of38(68%)patients.
Conclusions:Incriticallyillpatientswithacutehypoxemicrespiratoryfailurerequiringnoninvasiveventilation,
bronchoscopycanbeperformedwithanacceptablerisk.Sincethesepatientspersehaveahighlikelihoodof
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