FcγRI up-regulation induced by local adenoviral-mediated IFN-γ production aggravates chondrocyte death during immune-complex-mediated arthritis.docVIP

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FcγRI up-regulation induced by local adenoviral-mediated IFN-γ production aggravates chondrocyte death during immune-complex-mediated arthritis.doc

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FcγRI up-regulation induced by local adenoviral-mediated IFN-γ production aggravates chondrocyte death during immune-complex-mediated arthritis

Available online /supplements/5/S1 Meeting abstracts 23rd European Workshop for Rheumatology Research Marseille, France 27 February – 2 March 2003 Received: 14 January 2003 Published: 24 February 2003 ? 2003 BioMed Central Ltd (Print ISSN 1478-6354; Online ISSN 1478-6362) Autoantibodies and antigens 2 Investigation of the reactivity patterns of antifilaggrin antibodies in sera and synovial fluids from patients with rheumatoid arthritis using citrullinated synthetic peptides 1 Rheumatoid arthritis — class prediction by autoreactivity profiles R Bergholz1, F Schumann1, S Behrens1, U Ungethüm1, G Valet2, WA Schmidt3, GR Burmester1, JM Engel4, WJ van Venrooij5, G Steiner6, S Bl??1 M Brózik1, J Szakonyi2, A Magyar3, B Rojkovich1, R Tobi3, F Hudecz3, P Gergely2, K Merétey1 1National Institute of Rheumatology, Frankel Leo u 25, Budapest, Hungary 1Department of Rheumatology Clinical Immunology, Charité 2Central Laboratory of Immunology, Faculty of Medicine, Semmelweiss Medical University, Budapest, Hungary 3Peptide Chemistry Research Group, E?tv?s Lóránd University, Budapest, Hungary University Clinic, Berlin, Germany 2MPI Biochemistry, Munich, Germany 3Clinic for Rheumatology Berlin Buch, Berlin, Germany 4Rheumaklinik, Bad Liebenwerda, Germany 5Department of Biochemistry, University of Nijmegen, Arthritis Res Ther 2003, 5 (suppl 1):2 Antifilaggrin antibodies comprise a heterogeneous population of anti- bodies directed to citrullinated proteins. The Netherlands 6Divison of Rhematology, Department Internal Medicine III, Vienna Recent studies have shown that their production is highly specific for rheumatoid arthritis (RA) and the initial antigenic trigger for these autoantibodies can be localised to the inflammed synovial tissue. The aim of our study was to compare the reactivity and specificity of anti- bodies in sera and synovial fluids towards citrullinated epitopes. Peptide sequence corresponding to human profilaggrin (amino acid residues