Genome-assisted prediction of a quantitative trait measured in parents and progeny application to food conversion rate in chickens.docVIP
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Genome-assisted prediction of a quantitative trait measured in parents and progeny application to food conversion rate in chickens
Genetics Selection Evolution
BioMedCentral
Research
Open Access
Genome-assisted prediction of a quantitative trait measured in
parents and progeny: application to food conversion rate in
chickens
Oscar González-Recio*1, Daniel Gianola1,2, Guilherme JM Rosa1,
Kent A Weigel1 and Andreas Kranis3
Address: 1Department of Dairy Science, University of Wisconsin, Madison, WI 53706, USA, 2Department of Animal Sciences, University of
Wisconsin, Madison, WI 53706, USA and 3Aviagen Ltd., Newbridge, Scotland, UK
Email: Oscar González-Recio* - gonzalez.oscar@inia.es; Daniel Gianola - gianola@; Guilherme JM Rosa - grosa@;
Kent A Weigel - kweigel@; Andreas Kranis - akranis@
* Corresponding author
Published: 5 January 2009
Received: 16 December 2008
Accepted: 5 January 2009
Genetics Selection Evolution 2009, 41:3
doi:10.1186/1297-9686-41-3
This article is available from: /content/41/1/3
? 2009 González-Recio et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Accuracy of prediction of yet-to-be observed phenotypes for food conversion rate (FCR) in
broilers was studied in a genome-assisted selection context. Data consisted of FCR measured on
the progeny of 394 sires with SNP information. A Bayesian regression model (Bayes A) and a semi-
parametric approach (Reproducing kernel Hilbert Spaces regression, RKHS) using all available SNPs
(p = 3481) were compared with a standard linear model in which future performance was predicted
using pedigree indexes in the absence of genomic data. The RKHS regression was also tested on
several sets of pre-selected SNPs (p = 400) using alternative measures of the information gain
provided by the SNPs. All analyses were performed using 333 genotyped sires as training s
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