Genome-assisted prediction of a quantitative trait measured in parents and progeny application to food conversion rate in chickens.docVIP

Genome-assisted prediction of a quantitative trait measured in parents and progeny application to food conversion rate in chickens.doc

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Genome-assisted prediction of a quantitative trait measured in parents and progeny application to food conversion rate in chickens

Genetics Selection Evolution BioMedCentral Research Open Access Genome-assisted prediction of a quantitative trait measured in parents and progeny: application to food conversion rate in chickens Oscar González-Recio*1, Daniel Gianola1,2, Guilherme JM Rosa1, Kent A Weigel1 and Andreas Kranis3 Address: 1Department of Dairy Science, University of Wisconsin, Madison, WI 53706, USA, 2Department of Animal Sciences, University of Wisconsin, Madison, WI 53706, USA and 3Aviagen Ltd., Newbridge, Scotland, UK Email: Oscar González-Recio* - gonzalez.oscar@inia.es; Daniel Gianola - gianola@; Guilherme JM Rosa - grosa@; Kent A Weigel - kweigel@; Andreas Kranis - akranis@ * Corresponding author Published: 5 January 2009 Received: 16 December 2008 Accepted: 5 January 2009 Genetics Selection Evolution 2009, 41:3 doi:10.1186/1297-9686-41-3 This article is available from: /content/41/1/3 ? 2009 González-Recio et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Accuracy of prediction of yet-to-be observed phenotypes for food conversion rate (FCR) in broilers was studied in a genome-assisted selection context. Data consisted of FCR measured on the progeny of 394 sires with SNP information. A Bayesian regression model (Bayes A) and a semi- parametric approach (Reproducing kernel Hilbert Spaces regression, RKHS) using all available SNPs (p = 3481) were compared with a standard linear model in which future performance was predicted using pedigree indexes in the absence of genomic data. The RKHS regression was also tested on several sets of pre-selected SNPs (p = 400) using alternative measures of the information gain provided by the SNPs. All analyses were performed using 333 genotyped sires as training s

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