GLP-1及百泌达作用机制.pptVIP

CITATIONBarnett AH, Burger J, Johns D, et al. Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: a multinational, randomized, open-label, two-period, crossover noninferiority trial. Clin Ther. 2007;29:2333-2348. SEEpg 2342 “Hypoglycemia” (for slide data); pg 2335 “Study design” (for background information) DISCUSSION Incidence of hypoglycaemia in patients taking adjunctive sulphonylurea (SFU) was not different but was significantly less with exenatide/metformin (MET) compared w