冷循环射频与手术治疗肝癌的临床研究_0.docVIP

冷循环射频与手术治疗肝癌的临床研究 【摘要】 目的 研究 比较冷循环射频与手术 治疗 肝癌的疗效、并发症情况、住院花费、住院天数及生活质量。 方法 肝癌患者159例，分为两组：肿瘤直径≤5.0cm、单发肿瘤44例，手术治疗29例，冷循环射频治疗15例；肿瘤直径＞5.0cm患者115例，手术治疗54例，冷循环射频治疗61例。冷循环射频治疗采用Col-tip RFTM系统，于超声引导下将集束射频治疗针穿刺进入肿瘤进行治疗。分组比较两种治疗的肝功能、AFP改变、并发症情况、住院天数及花费、生活质量评分等。描述影像学变化。结果 冷循环射频治疗对患者肝脏功能的破坏小于手术治疗。冷循环射频治疗和手术治疗对患者AFP水平的 影响 没有明显差异。冷循环射频治疗并发症发生率，住院天数及花费低于手术治疗，术后生存质量高于手术治疗。肿瘤直径≤5.0cm、单发肿瘤，冷循环射频和手术1年生存率及中位生存时间没有差异。结论 相对于手术，冷循环射频治疗也是一种安全，有效的肝癌治疗方法。 【关键词】 射频 手术 肝癌 生活质量 Clinical study of the application of radio frequency ablation and operation on treatment of liver cancer 【Abstract】 Objective To probe into the treatment effect，complications rate，life quality and hospitalization expenses of applying radio frequency ablation (RFA) to treat liver cancer and compare to which of the operation.Methods 159 liver cancer patients were included in this study. The y were divided into two groups according to the diameters of thEir tumors and whether thEIr tumors were solo.Among 44 cases in the group of solo tumor with tumor diameters equal and less than 5.0cm，29 cases received operations and 15 received radio frequency treatments，among 115 cases of the group with tumour diameters more than 5.0cm，54 cases received operations and 61 received radio frequency treatments.The operations were hepatolobectomy.Radio frequency treatment were conducted either percutaneously or intraoperatively under the guidance of ultrasound.The bundled needles were punctured into the tumors and performed radio frequency treatments，with treatment frequency of 480kHz，treatment time 12min.Collected data of liver function（ALT，ALB，TB），AFP，complications，hospitalization days and expenses of patients receiving operations and radio frequency treatments respectively，observed changes in radiology.Differences between the above-mentioned data of patients received operations and radio frequency treatments within two groups were compared.Results The damaging effect of liver function of radio frequency treatment was less seve