注射用甘露聚糖肽致严重过敏性休克1例.pdfVIP

案例分析 Case Analysis 注射用甘露聚糖肽致严重过敏性休克1例 张传洲，王腾，刘黎莎，张月君，陈杰* 青岛大学附属医院药学部，山东青岛 266003 [摘要] 注射用甘露聚糖肽为免疫增强药，主要用于恶性肿瘤放、化疗中改善免疫功能低下的辅助治疗。常见不良反应有胸 闷、呼吸困难，瘙痒、皮疹、红斑、风团、寒战、发烧、严重时可引起过敏性休克。本文报告1例应用注射用甘露聚糖肽致严 重过敏性休克的病例。提示在应用甘露聚糖肽时，应详细询问过敏史，严格做好皮试，一旦有过敏反应出现，须迅速做出反 应，以免贻误治疗时机。 [关键词] 甘露聚糖肽 不良反应 过敏性休克 [中图分类号] R96 [文献标识码] A [文章编号] 1672-2809(2015)22-0042-02 1 C e of S ve e Alle gi Sh I d ced by e I j c io of M o 1Caøeø of御VCRADeqPC SI础hIIJCedbydIO闻eCIiOa. ofMannoøe Zhang Chuan-zhou, Wang Teng, Liu Li-sha, Zhang Yue-jun, Chen Jie * Pharmacy department, Affiliated Hospital of Qingdao University, Qingdao Shandong 266003, China [Abstrract] A t t The injection of the drug of the immune enhancement is mainly used in the treatment of malignant tumor, chemotherapy and improve the immune function. The common adverse reactions are chest tightness, shortness of breath, itching, rash, erythema, wheal, chills, fever, more severely can cause anaphylactic shock. In this paper, we report 1 cases of severe allergic shock caused by injection of mannose. In the application of Mannatide, patient should be asked in detail about the history of allergy, strictly do skin test, once allergic reaction, to respond quickly, so as not to delay treatment timing. Key w rd ] Mannose; Adverse Reaction; Allergic Shock. [Keyworos] 甘露聚糖肽为免疫增强药，其常见不良反 脉推注地塞米松10mg，同时立即停用静脉输液，建 应有胸闷、呼吸困难，瘙痒、皮疹、红 立静脉通路，给予5%葡萄糖氯化钠持续滴注，给予 斑、风团、寒战、发烧、严重时可引起过敏性休 面罩吸氧，症状无明显缓解，面色青紫，考虑药物 克。现将一例支气管哮喘患者应用甘露聚糖肽致严 过敏所致感染性休克，立即给予心电监护，10:10监 重急性过敏性休克报告如下。 测血压60/45mmHg 、血氧饱和度65% 、呼吸困难， 意识不清，立即给予胸外按压，先后给予地塞米松 1 病例汇报 10mg静推、肾上腺素1mg每隔3min静推、尼可刹米 患者男，60 岁，因“肝恶性肿瘤介入治疗2年 0.375g静推、二羟丙茶碱缓慢静推；10:15下病危， 余”于2015年7 月28 日入院，既往患者慢性乙肝病 充分向患者家属说明病情及抢救方案