定抽颗粒治疗小儿多发性抽动症临床及实验研究.pdf

( ) • 399 • 中华中医药杂志 原中国医药学报 2011年2月第26 卷第2 期 CJTCMP , February 2011, Vol . 26, No.2 ·研究报告· 定抽颗粒治疗小儿多发性抽动症的临床及 实验研究 朱先康，韩新民，王敏华 （南京中医药大学附属医院儿科，南京 210029） 摘要： 目的：观察益肾平肝豁痰法治疗小儿多发性抽动症的临床疗效及探索其作用机制。方法：采用随机 对照的方法，以泰必利为对照药物，治疗小儿抽动症60例；建立小儿多发性抽动症的动物模型，研究定抽颗粒 治疗小儿多发性抽动症的药理作用，结果：定抽颗粒治疗疗效优于泰必利（P0.05）。定抽颗粒能够明显减少 亚氨基丙二腈（IDPN）致多发性抽动症模型小鼠刻板行为和运动行为（P0.01）、能降低模型小鼠自主活动数 P P （ 0.05）、能使模型小鼠脑内5-羟吲哚乙酸含量降低（ 0.01）。结论：定抽颗粒是治疗小儿多发性抽动症较 为理想的中药制剂。 关键词：多发性抽动症；益肾平肝豁痰法；定抽颗粒；泰必利 基金资助：江苏省中医药局中医药科学技术研究专项课题（No.H05038） Clinical and empirical research on treatment of children TS by Dingchou Granule ZHU Xian-kang, HAN Xin-min, WANG Min-hua Department of Paediatrics, Affi liated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China （ ） Abstract: Objectives: To study the effect of nourishing kidney, calming liver and resolving phlegm on children TS and to explore its mechanism. Methods: In a random way, the control group was administered with Tiaprid, the sixty patients were given with TS; Established animal model of children TS, to study the pharmacodynamic action of Dingchou Granule on TS. Results: Dingchou Granule was more effective than Tiaprid (P0.05). Dingchou Granule could signifi cantly improve stereotyped and motor behavior in mice models caused by IDPN (P0.01) and could reduce the number of indepe