171例儿童严重药品不良反应文献分析.pdfVIP

中国药物警戒第 10 卷第 7 期 2013 年7 月 July , 2013, Vo l. 10, NO.7 中图分类号:R994.11 文献标识码:A 文章编号:1672-8629(2013)07-0427-05 171 例儿童严重药品不良反应文献分析 许顺贵赵尚清王永红(武警北京市总队医院药剂科，北京 1∞027) 摘要:目的对儿童严重药品不良反应文献进行分析，了解儿童药品不良反应发生的基本情况及其特点。方法以儿 童用药、不良反应为关键词，通过中国知网(CN阻)中文期刊检索了 2∞0-2013 年与儿童用药不良反应相关文 献，对严重药品不良反应进行统计分析。结果儿童严重药品不良反应涉及主要为抗微生物药物、中药制剂、抗癫痛 药物、解热镇痛药物。不良反应主要表现为:全身性的严重过敏反应、以严重皮摩、皮炎、多形性红斑为主的皮肤及附 件损害、以及血尿、蛋白尿等的泌尿系统损害。结论医院应重视临床抗微生物药物和中药制剂的合理使用，注意收 集儿童用药安全信息，重视药品不良反应监测及上报工作，保障患儿安全用药。 关键词:儿童;严重不良反应;文献研究 Literature Analysis of 171 Cases of Severe Adverse Drug Reactions in Children XUShun-阴i ZHAO Shang-qing W ANG Yong-hong 但eijing Armed Police Corps Hospit泣， Beijing 100027,China) Abstract: Objective To analyze the literature of adverse drug reaction(ADR) of children, to understand the regularity and features of ADR. Methods Using pediatric drug and adverse reaction as the keywords , searched the online joumals of CNKI for children ADR reported in China between 2000-2013 , and analyzeed the severe ADR. Results The severe ADR in children associated drug mainly involved the antimicrobial drugs, Chinese medicine preparations , antiepileptic drugs, and analgesic-antipyretic drugs. The manifestations ofthe severe ADR include severe systernic allergic reaction, dermatitis, skin and adnexa darnage , hematuria and proteinuria of urinarγsystem darnage. Conclusion More attention shoud be paid to the management of antirnicrobial drugs and Chinese medicine preparations. The hospital should collect information on medicines in children. Pay attention to the work of monitoring of ADR cases to ensure the safety of medication in children. Key words: children; severe adverse drug reaction; literature research 系指 18 岁以下的任何人，除非对其适用之法律规定成 儿童用药安全一直广受社会关注，由于儿童的生理 年年龄低于18 岁。本文将儿童的年龄范围定为0-18 岁。 状况和成人不同，对药物的代谢过程等