肠道原发性非霍奇金淋巴瘤85例分析.PDFVIP

·534 · 南方医科大学学报（J South Med Univ ） 2012;32(4) 临床研究 肠道原发性非霍奇金淋巴瘤85例分析 冉文斌，欧阳钦 四川大学华西医院消化内科，四川 成都 610040 摘要：目的 了解不同细胞来源的肠道原发性非霍奇金淋巴瘤（PINHL）在临床特征、内镜表现、诊断及治疗、预后方面的差异。 方法回顾性分析我院2003 年1月~2010 年12月间明确诊断的PINHL 病例，分别统计B 细胞来源与T 细胞来源的PINHL 在临床 表现、内镜表现、诊断治疗，并随访预后。结果共纳入PINHL 85 例，中位年龄52 岁，男女比例为3.05 ∶1，B 细胞来源58 例 （68.2%），T 细胞来源27 例（31.8%）。T 细胞淋巴瘤较B 细胞淋巴瘤具有发病年龄小（32 岁vs 56岁，P0.01) ；发热、便血、腹泻、盗 汗多（P0.05）；病变以多部位弥漫性分布和肠镜下以溃疡及溃疡浸润性表现为主；确诊时间长（4 月vs 2 月，P0.01）；误诊率高 （16/27 vs 12/58 ，P0.01）；预后差等特点；且T 细胞淋巴瘤以结外NK/T 淋巴瘤为主。结论我院PINHL 中，T 细胞来源淋巴瘤比 例高，发病年龄更早，诊断困难，容易误诊，总体预后差，病理分型以结外NK/T 淋巴瘤为主。 关键词：非霍奇金淋巴瘤；肠道淋巴瘤；T 细胞淋巴瘤；B 细胞淋巴瘤 中图分类号：R574 文献标志码：A 文章编号：1673-4254（2012）04-0534-05 doi: 10.3969/j.issn. 1673-4254.2012.04.021 /kcms/detail/44.1627.R1800.014.html Primary intestinal non-Hodgkins lymphoma: a retrospective study of 85 cases RAN Wenbin, OUYANG Qin Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu 610040, China Abstract: Objective To review the clinical characteristics and treatment outcomes of primary intestinal non-Hodgkins lymphomas (PINHL) and analyze the differences between T-cell and B-cell lymphomas. Methods The characteristics of PINHL patients treated in our hospital between January 2003 and December 2010 were reviewed for their clinical manifestations, diagnosis, endoscopic findings, treatments and outcomes. Results Eighty-five cases of PINHL meeting the Dawsons criteria were identified. The median age of the patients at the time of diagnosis was 52 years and the male: female ratio was 3.05:1; 58 cases (68.2%) had B-lineage and 27 cases (31.8%) had T-cell lineage lymphomas. Compared to those with B-cell lymphoma, patients with T-cell lymphomas showed a younger age of disease onset (32 vs 56 years, P0.01) and presented with a greater