奥派对精神分裂症患者认知功能的影响_孙群星.pdfVIP

DOI: 10. 13342 /j .c ki .cjhp.2006.04.029 ·424· 　 2006 14 4　　Chi a Jour al of Health Psycholog y　2006, Vol 14, No. 4　 ① 孙群星 　郭　华　刘　勇　杨传友　李素华　朱玉星　张爱荣 【】　　探讨奥派治疗对分裂症患者认知功能的影响。　以入院顺序分层随机法,将奥派与维 通治疗精神分 裂症各 40例作对照研究,在治疗前和治疗后 2、4、 8、 12周末,用阳性症状及阴性症状量表( PANSS) ,不良反应量表( TESS) 评定疗效及副反应,用韦氏成人智力量表(W AIS- R)、韦氏记忆量表(WM S)和威斯康星卡片分类 测验( W CST)评定治疗 前后患者认知功能的改变。 分析量表中各领域的计分。　两组P AN SS 总分在治疗后与治疗前比较有显著性差异(P 0. 01) ,奥派组有效率 92. 5% ,显效率 80% ;维 通组有效率 90% ,显效率 80%。两组间疗效无显著性差异( 0. 05) ,且 P 两组言语量表、操作量表、全量表和记忆量表分比治疗前明显提高。治疗后 8、12周末 TE SS 评分,研究组均低于对照组,有 显著性差异(P 0. 01)。 　奥派治疗精神分裂症疗效确切,且安全性高, 对认知功能的改善彻底。 【】　奥派;维 通;分裂症;认知功能 Effect of Aripiprazol e on Coginiton Function in Patients with Schizophrenic. Sun Qunx ing , Guo Hua , L iu Yong , et al. , 463000, . . Zhumadian M ental Hosp ital Zhumadian P R China 【Abstract】　Objective　To i vestigate the effect of aripiprazole o cogi ito fu ctio i patie ts with schizophre ia. Methods 　40 . schizophre ic patie ts w ere treated w ith sisperido e as the co trol group The Positive a d Negative Sy drome Scale ( PANSS) , while the adverse eve ts w ere determi ed by the treatme t emerge t symptoms scale ( TESS) , W AIS- R, , 2, 4, 8, 12 WMS W CST were evaluated before treatme t a d after weeks treatme t respectively by me as of a alyzi g th e scores i every domai s. Results　There were sig ifica t deffere ce i total scores of PAN SS before treati g after treati g ( 0. 01). 92. 5% , 80% . relatively P The efficacy rate of aripiprazole group was i w hich w ere improved markedly The eff