自己免疫性肝病(国外英文资料).docVIP

自身免疫性肝病(国外英文资料) Autoimmune liver disease (1) the etiology of AIH has not yet been fully elucidated, and may be the result of complex interactions, such as induced factors, autogenic antigen, genetic predisposition, and immune regulation. Existing indirect evidence to suggest that: (1) AIH potential genetic susceptibility of background, northern Europe and North America, white the crowd type I AIH is the main susceptibility alleles of the HLA - DRBl 0301 and HLA - DRBl 0401; AIH may be associated with a variety of immune regulatory defects that control its own response; The occurrence of AIH in susceptible individuals may require a trigger, such as a hepatovirus infection, or specific reactions to drugs and other hepatotoxic substances; (4) the final effect mechanism of tissue injury may involve autoantibodies and expression in liver cells on the surface of the reaction of liver specific antigen (ADCC), and direct cytotoxic effects of T cells to liver cells appear relatively minor. (2) the PBC exact pathogenesis remains unclear, but think of bile duct injury is caused by the immunological disorders, now understand main complex (MHC) host susceptibility genes associated with the onset of the disease, mainly is the MHC Ⅱ type of molecular DR3 6 times, DR2 is higher than the control group. Many of the studies have been linked to infection, including infections in the gut, infection of mycobacterium mycobacterium, and infection of mycoplasma. Recently, some people have suggested that the possibility of retrovirus infection may even be useful in the treatment of primary biliary cirrhosis. (3) the PSC is an unknown cause of chronic bile stasis, characterized by inflammation of the liver and/or extrahepatic bile duct inflammation and fibrosis, and eventually develops into cirrhosis of the liver. Several etiological hypotheses have been put forward, such as chronic portal bacteremia, the toxic effects of intestinal bacterial toxins or bile acid, chronic viral infection, isc